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doi: 10.1038/ng.924 55 TedeschiPMPMJohnson-FarleyNLinHSheltonLMOogaTMackayGMGet al

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Figure EV7 BSO sensitivity in the A549shNRF2-BIND rescue system and mechanistic characterization of A-485 treatment in NRF2-dependent NSCLC models

HMGB1 binds to its receptor, namely receptor for advanced glycation end products (RAGE) to trigger the downstream inflammatory response and produce various pro-inflammatory mediators, like tumour necrosis factor-alpha (TNF-) and interleukin-1beta (IL-1), leading to neuroinflammation and neuronal apoptosis (Lotze and Tracey 2005)

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