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In addition to iron, infection, inflammation, and hypoxia can alter hepcidin expression [4]

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doi: 10.1126/science.1120411

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2 The adenylation loop abuts the E-flap moiety, which is a conserved loop containing a catalytic glutamate that can close over the amino acid and ammonia half-site of the active site (Figure 1)

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10591084, Sechi, G., et al

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