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The activation of the Notch signaling pathway and significant methylation on the CpG islands of the HIST2H2BF gene result in the development of colorectal CSC traits and an enhanced capacity for the cancer to metastasize to the liver [219]

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13 C NMR (100 MHz, DMSO-d 6 ) = 61.2, 55.8, 33.2, 31.4

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Oncotarget (2014) 5:79823.10.18632/oncotarget.2352 36 ValenciaTKimJYAbu-BakerSMoscat-PardosJAhnCSReina-CamposMet alMetabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis
