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Patients with a history of alcohol abuse, hepatitis or cirrhosis are at higher risk of acetaminophen toxicity, as they already have underlying liver damage. Rather than eliminating acetaminophen entirely, Lee wanted to modify its structure to reduce the harmful effects of NAPQI

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High Toxin Load Environmental toxins such as dioxins, pesticides, polychlorinated biphenyls (PCBs), and phthalates are endocrine-disrupting compounds (EDCs)