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To evaluate if knockout of ABCC1 also enhances the anti-leukemic effects of AZD-4320 in vivo, we transplanted equal numbers of MOLM-13 AAVS1.1 control or ABCC1 -knockout cells into NSG-S mice and treated them once a week with either AZD-4320 (10 mg/kg) or vehicle

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(2019) 34:e2694

However, a more recent multicenter, open-label RCT (ISRCTN 53817913) demonstrated that addition of diaphragm pacing to standard care with non-invasive ventilation was associated with decreased survival and should not be used as a treatment for ALS patients [66]

[Google Scholar] 109.Varghese JM, Bhat V, Bhat GS, Rao N

doi: 10.3389/fimmu.2017.01239