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Clinically, treatment with metformin significantly lowers 11-dehydro-thromboxane B 2 (11-dhTxB 2 ) levels and mean platelet volume (MPV), indicating a reduction in platelet activation ( Sulfonylureas have demonstrated a reduction in ADP-induced platelet adhesiveness and platelet aggregation in preclinical studies (Klaff et al., 1981

[DOI] [PubMed] [Google Scholar] 36.Roberts AL, Lyall K, Rich-Edwards JW, et al

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doi: 10.1111/andr.2015.3.issue-3 88 SafarinejadM