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266,267 Also, BCAA supplementation can increase CD8 + T cells to upregulate glucose transporter GLUT 1 in a FoxO1-dependent manner, increase glucose uptake and utilization, and enhance the antitumor activity of CD8 + T cells, having a synergistic role with anti-PD-1 therapy

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Thus, excessive CB1 activation with exogenous THC may lead to NMDAR hypofunction which in turn downregulates genes involved in synthesis, recycling and utilization of GSH in developing neurons, promoting oxidative stress

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