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The increase of intracellular ATP levels hesitates in the closure of plasma membrane K+ channels, thus triggering -cell depolarization

A: It should be stored in a cool and dry place

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Moreover, it should be noted that the accumulation of fructose has been suggested to be more deleterious than that of glucose [75, 81] as fructose metabolism by fructokinase bypasses key-regulated steps of the glycolytic pathway [82] and thus can deplete intracellular phosphate and ATP, thereby inducing oxidative stress and inflammation [83]

In these ways, IH induces abnormal vasoconstriction and elevates systemic blood pressure