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Intermediate cells in the TME (e.g., endothelial cells, TAMs) express high levels of IDO and TDO, leading to tryptophan depletion, which inhibits T cell proliferation and function, causing cell cycle arrest at the G1 phase
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Am J Epidemiol 165:955965
Blood levels of acetaminophen are also determined to guide treatment (Ferner 2011
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