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The corresponding blots are shown in Extended Data Fig

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In TGF-1-induced fibroblast activation models, baicalin inhibits SMAD3 nuclear translocation and suppresses transcription of COL1A1 and ACTA2 (-SMA), thereby preventing ECM remodeling and myofibroblast conversion

Khan, D., Miller, J.L., Girard, I.J., Chan, A., Kirkbride, R.C., Pelletier, J.M., Becker, M.G., Yeung, E.C., Stasolla, C., Goldberg, R.B., Harada, J.J., and Belmonte, M

1d ranged from a modest 28.7% inhibition at 67 M to robust activity with IC 50 = 2.5 M (Table 1)
