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In contrast, GAA and the ferroptosis inhibitor liproxstatin-1 (Lip-1) significantly activated the NRF2/SLC7A11/GPX4 signaling pathway and mitigated A 25-35 -induced neuronal injury (Lu et al., 2025)

Abstract The enzyme vanin-1 produces pantothenic acid (PA) and cysteamine, but the role of the vanin-1 /PA axis in metabolic and cardiovascular diseases remains less explored than the vanin-1 /cysteamine pathway

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Not only disruption of the clock genes but also chronic circadian disruption or/and ablation of crucial metabolic transcriptional co-regulators such as SRC-2 (Steroid Receptor Coactivator-2) can affect metabolic homeostasis