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Studies on autosis are still in their infancy, and the mechanism leading to cell death may be related to excessive membrane depletion, disruption of cholesterol metabolism in the ER/external nuclear membrane or altered ion transport and osmotic pressure in the plasma membrane

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doi: 10.1016/j.chom.2010.10.005 14 MiagkovAVKovalenkoDVBrownCEDidsburyJRCogswellJPStimpsonSAet al

But the question remains: does peptide therapy really work

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