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Li N, Liu B, He R, Li G, Xiong R, Fu T, Li D, Xu C, Wang B, Geng Q

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For the control group, after the same initial treatment, the FOXO4-DRI was replaced with an equal volume of PBS

ACE2 enzyme degrades ANG II, the major effector of the RAAS that increases hypertension (by lowering baroreceptor sensitivity) to control heart rate, up-regulate vasoconstriction, sodium retention, OxS, inflammation, and fibrosis 300

Hegewald MJ, Markewitz B, Elliott CG