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Specifically, it can lead to major birth defects of the brain and spine called neural tube defects (NTD)

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Baseline and interval laboratory monitoring should include: fasting glucose and HbA1c (tirzepatide can cause hypoglycemia in non-diabetic subjects if caloric intake drops too low), lipase and amylase (pancreatitis risk with GLP-1 agonists), liver function tests (AST, ALT, bilirubin), and thyroid panel (TSH, free T3, free T4)

For metabolic optimization rather than pure weight loss: MOTS-c may improve mitochondrial efficiency Tesamorelin may improve body composition Semaglutide improves glucose control Tirzepatide offers the strongest overall metabolic effects Frequently Asked Questions Is AOD-9604 the same as growth hormone

Some participants achieved 20% weight loss when treatment was continued