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The combination is generally safe, as both compounds are well-tolerated individually

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Interestingly, however, animals treated with the humanized antibody showed reduced regeneration [161], suggesting that mechanisms of protection were different from that seen with the rodent anti-HMGB1 treatment [159]

With the potential to shift from a patient- and disease-centered approach to a preventive person-centered health approach, the model spans all levels and units of action to achieve better public health of nations that emerge from improved individual health

10.1136/thx.2007.086199

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