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Trial populations differ from real-world MASH patients, who often have diabetes, advanced fibrosis, and comorbidities that modify both efficacy and risk

Arbez N, He X, Huang Y, Ren M, Liang Y, Nucifora FC, et al

This helps ensure that a greater proportion of the weight lost comes from fat, leading to a healthier, leaner body composition

however, the 6h/day exposure triggered increased levels of proteins involved in the inflammatory response (e.g., IL-6, IL-8, and TNF-) and degradation of extracellular matrix/fibrosis (e.g., MMP-3 and uPAR) (Table 4

[172] utilized B16F10 murine melanoma cells and reported similar observations