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However, modern research indicates that GCGR agonism increases thermogenesis and energy expenditure through the activation of futile cycles in the liver and potentially the recruitment of brown adipose tissue

[DOI] [PubMed] [Google Scholar] 208.Jabbour S.A., Frias J.P., Guja C., Hardy E., Ahmed A., Ohman P

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A synthetic glucagon-like peptide-1 analog with improved plasma stability

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Additionally, the appetite suppression that makes these medications effective for weight management may inadvertently reduce overall fluid intake, as patients often consume less food and beverages throughout the day