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Nisha Dahiya +2 more Table of Contents Glucagon-like peptide-1 (GLP-1) medications are gaining popularity for their benefits for type-2-diabetes and weight management 1

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Collectively, evidence from both clinical studies and animal models (Table 4) demonstrates that while leptin supplementation is effective in cases of leptin deficiency, mutations in the leptin receptor, decreased receptor expression, or impairments in downstream signaling components result in leptin resistance, wherein exogenous leptin administration does not elicit meaningful weight-reducing effects