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In people living with obesity, research has shown that dopamine signalling in the striatum a key reward-processing area can become dysregulated, requiring ever-greater stimulation to generate the same sense of reward

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He shared this framework: If roughly 10% of the population is on GLP-1s and those consumers are drinking about half as much as they used to that alone implies a ~5% decline in alcohol consumption

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Unrealised Expectations Despite progress, several anticipated 2025 milestones did not come to fruition: Regulatory progress stalled: FDAs obesity drug guidance, published in draft form in January 2025, remains unfinalised, whilst EMA has yet to update its 2016 guideline