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Adipose tissue, particularly visceral fat, is metabolically active and produces pro-inflammatory cytokines including TNF-alpha, IL-6, and leptin

So, you'd think someone in my immediate environment might have mentioned it

First cardiovascular safety trial of a DPP-4 inhibitor in patients with T2DM and high cardiovascular risk, showing that saxagliptin does not augment MACE but increases hospitalization for heart failure

Glucagon-Like Peptide-1 Receptor Agonist (GLP-1 RA) and dual agonist clinical guidance Herts and West Essex ICB

This is why the subcutaneous GLP1s+ injections have been so much more effective than orals (e.g., Zepbound at 22% weight loss v.s

Both Nirchi and Long point to things like nausea and constipation, particularly when starting the drugs or titrating up to a higher dose (but for them, the benefits have outweighed the downsides)