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Already used as a drug to treat hypoglycaemia, DiMarchi began working on finding a better way to synthesise glucagon so that it could be administered more easily

The drugs also help slow digestion, which causes less glucose to enter the bloodstream

Glucagon-like peptide-1 receptor agonist Exendin-4 improves neurological outcomes by attenuating TBI- induced inflammatory responses and MAPK activation in rats

Although, as said above, weight loss induced by GLP-1 RAs comes mainly from reductions in fat mass rather than lean mass, nutritional advice and exercise programmes to achieve muscle strengthening are recommended to minimize sarcopenic risk [74]

Aim for 0.7-1 gram of protein per pound of body weight to preserve muscle mass during weight loss

While these findings are encouraging, the underlying mechanisms remain unclear, and further evidence is needed to determine whether these effects are mediated by anti-inflammatory pathways