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Dehydration and electrolyte disturbances: Gastrointestinal side effects, particularly vomiting and diarrhea, can lead to dehydration and electrolyte imbalances

Clinical decision-making should be individualized, considering the patient's complete metabolic profile, disease severity, and treatment goals

Binding (Active) Site DPP4 has two main binding pockets, termed S1 and S2 (Figure 2b)

lifetime decreased medical expense $62K JAMA Health Forum (2025): Showed that the cost per quality adjusted life year (QALY) for tirzepatide (Zepbound) was $197K and the cost per QALY for semaglutide (Wegovy) was $468K

These agents not only improve AHI and patient-reported sleep quality but also significantly impact weight loss and metabolic health, thereby targeting the underlying contributors to OSA progression

How would benefit, no benefit or harm be measured