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Diabetes mellitus, a condition that significantly elevates the incidence and mortality risks associated with cardiovascular diseases, exacerbates the disease burden in China

Abstract Estimates suggest that there are currently 122.8 million adults 6599 years of age living with diabetes, of whom 9095% are diagnosed with type 2 diabetes (T2D)

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Evidence now warrants a focus on the beta cell itself and how to avoid its dysfunction, which is putatively caused by cytokine-driven inflammation and other stress factors, leading to low insulin-secretory capacity, autoantigen presentation and immune-mediated destruction