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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion
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A head-to-head clinical trial by Mounjaro manufacturer Eli Lily has claimed its tirzepatide-based jab is superior to Wegovys semaglutide-based formula.
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