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However, how much relative GIPR to GLP-1R agonism is optimal, and whether biased agonism is rending a unique virtue to the clinical efficacy of tirzepatide are challenging, but tractable, questions requiring additional study

These examples underscore the potential for GLP-1 RAs to address a wider range of health challenges in the future

25 June 2025 Drugs like Ozempic might seem like the latest fad but people can take comfort that this class of medications has been around for decades, writes Dr Natalie Nanayakkara, Endocrinologist and researcher at the Baker Heart and Diabetes Institute

Decreased Insulin Needs GLP-1s help the body become more sensitive to insulin, which can lead to significantly lower insulin doses

GLP-1 (Glucagon-Like Peptide-1) is primarily produced in enteroendocrine L-cells located in the distal small intestine (ileum) and colon in response to eating

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper