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At present, the strongest evidence supports appropriate use of each therapy on its own, based on established indications

Real-world evidence shows GLP-1 agonists lower the need for percutaneous coronary interventions and other revascularization procedures especially in patients who have already had an MI [61]

Upon FDA approval, the Ozempic warning label states that semaglutide may cause harm to the fetus and that women should stop the diabetes drug at least two months before planning a pregnancy

The SURPASS clinical trial program demonstrated superior A1C reductions compared to semaglutide, with many patients achieving normal blood glucose levels

The non-homeostatic pathway differs between individuals because of variations in hormonal status, epigenetic markers and personal experiences

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