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How GLP-1 drugs might work Scientists have proposed several theories to explain why GLP-1 drugs act on the brain

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They reduce blood sugar, promote weight loss, and lower cardiovascular risk in appropriate patients

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These gut-derived hormones are released in response to food intake, and have the following effects: Promoting insulin release (insulin lowers blood sugar) Blocking glucagon release (glucagon raises blood sugar) Delaying gastric emptying to prevent post-meal highs Promoting a feeling of fullness so you eat less at any given meal Previously approved incretin-based therapies mimic only the GLP-1 hormone