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A new study compared the effects of semaglutide or tirzepatide with other antidiabetic medications such as insulin and metformin on optic nerve conditions, including NAION, in patients with type 2 diabetes

5 Figure 1: Effect of once-weekly tirzepatide, compared with semaglutide, on lipid profile 5 GLP-1s are also being investigated for the prevention and treatment of heart failure

The strongest approach is both

If genetic testing reveals low predicted responsiveness to GLP-1 alone, PlexusDx counselors discuss realistic expectations, combination peptide protocols, and the importance of long-term adherence rather than rushing to add risky off-label combinations

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