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On the other hand, castrated females would not only respond similarly to intact ones, but treatment with GLP-1As could reverse part of the metabolic problems associated with estrogens reduction (Handgraaf et al., 2018

6 (10), e1001133 (2010)

A recombinant human glucagon-like peptide (GLP)-1-albumin protein (Albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis
Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions
Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats

They include a sluggish metabolism, vitamin and mineral deficiencies, and even resistance to insulin
