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Up to 70% of patients who undergo gastrectomy may develop vitamin B12 deficiency 1224 months after surgery if not supplemented with the vitamin [72,73]

Additionally, it was demonstrated, that failure PINK/PARKIN axis expression favors the accumulation of defective mitochondria that are not removed from the cells due to the impaired lysosomal system which in consequence promotes cellular damage, generates oxidative stress, and impairs sensitivity for insulin [60]

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References National Institutes of Health

Fujita, S