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Exploring targeted degradation strategy for oncogenic KRASG12C

Interestingly, first procaspase-activating compound (PAC-1), a proapoptotic protein required for procaspase-3 activation, operates by sequestering inhibitory Zn ions bound to the proenzyme, leading to caspase-3 autoactivation and apoptosis progression [89]

however, only if Glutathione can reach the site of inflammation intact [7]

Western blot analysis revealed decreased expression of ferroptotic modulator glutathione peroxidase 4 (GPX4)

Pepsingold colloid conjugates: preparation, characterization, and enzymatic activity

Still, we discovered weak GSH-dependent reductase activity with GAPDH-SG