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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinsons disease are typical amyloid

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[DOI] [PMC free article] [PubMed] [Google Scholar] 163.Levine L.D., Kim K., Purdue-Smithe A., Sundaram R., Schisterman E.F., Connell M., DeVilbiss E.A., Alkhalaf Z., Radoc J.G., Buck Louis G.M., et al

Given that iron is essential for mitochondrial FeS cluster and heme biogenesis, myelination, and monoaminergic neurotransmitter synthesis, nonselective iron chelation when iron burden is low, or iron availability is constrained, could theoretically precipitate or exacerbate functional iron deficiency and an energetic crisis [19, 23, 123]

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