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Li et al., 2014)

Acta Parasitol

Whats new from research: Mechanism is clear
Notably, Nrf2 plays a dual protective role by both repressing neuroinflammatory signaling and promoting the transcription of antioxidant genes, establishing it as a compelling therapeutic target in neurodegenerative disorders [182, 183]

Additional analysis of metabolomics data showed that the levels of fumarate and malate, metabolites downstream of complex II in the TCA cycle (Figure 7E), were increased in cKOt (Figure 7F)
Hertel SP, Winter G, Friess W
