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Despite the impressive success of immune checkpoint inhibitors across various tumor types, tumor cells can circumvent immune system attacks through several mechanisms, undermining the therapeutic potential of ICIs (183, 184)

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A small percentage of mice with only one copy of the GPx-1 allele and complete deficiency of GPx-2 develop mild ileocolitis (GPx-1 +/ GPx-2 / ), whereas a single copy of the GPx-2 gene (GPx-1 / GPx-2 +/ ) protects against inflammation, leading to the suggestion that GPx-2 has a greater protective effect in the intestine than GPx-1 (114), although an earlier study reported that one copy of either of these GPx genes was sufficient to prevent the development of intestinal cancer (72)

Detected bacteria in bile include E

Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states