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A previous study has also demonstrated that systemic administration of KA induces contraction and even death of piriform cortical neurons

We measured cell viability upon treatment with etoposide and TBHP and found that cell death rate was significantly increased in GPX4-knockdown LCL-K cells compared with that of control LCL-K cells after treatment with TBHP ( P = 0.0111, Fig

Although some studies indicate that ethnic and environmental factors, in addition to genetic factors, can also influence on disease progression, the caution should be exercised in drawing too hasty conclusions

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Although an effective inflammatory response plays a protective role, persistent or excessive inflammatory activity in the central nervous system (CNS) contributes to the pathogenesis of both acute and chronic neurological conditions [48]

These studies suggest that ammonium accumulation may induce programmed cell death of immune cells within TME, such as NK cells, through oxidative imbalance and mitochondria-mediated autophagy, thereby promoting immune evasion by prostate cancer cells