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Transcription factors YAP/TAZ, which reside downstream of VEGF/VEGFR-2, are upregulated on stiffer matrices and in disturbed flow, and in vivo inhibition of YAP/TAZ caused decreased atherosclerosis and EC inflammation (83, 84)

As outlined in the introduction, international or national food safety authorities assess toxicity data available from animal experiments and mode of action information for some major mycotoxins to derive TDI values or advice to apply a MoE approach to assess risks for carcinogenic and genotoxic mycotoxins

Fe 3+ , Cu 2+ ) it is known to directly target cellular lipids, proteins, nucleic bases, causing DNA base modification or fragmentation[5]

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