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PubMed Pickart L, et al

ARA-290 recalibrates immune signaling toward repair without broadly suppressing immunity, which makes it attractive for patients who need targeted inflammation control rather than blanket immunosuppression

ER has less of a role in the classical estrogen target tissues and has been found to be more dominant in the brain, cardiovascular system and the colon [87, 88]

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Secondly, the relative orientations and distance of two membrane-proximal regions are also significantly different between these two complexes, which to a certain extent could explain why HGF and NK1 have different ability in triggering c-MET activation

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