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doi: 10.1152/physrev.00019.2012

J Sleep Res, 10.1111/jsr.12001 (2012)

In rodent models with dopaminergic lesions resembling Parkinsons conditions, it improved behavioural outcomes and showed neurorestorative effects on surviving neurons

Peptide therapeutics have emerged as promising agents in gerontological medicine, targeting multiple hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis (protein homeostasis), mitochondrial dysfunction, and cellular senescence ( This review examines nine peptides with demonstrated or potential applications in age-related conditions: tirzepatide, epitalon, GHK-Cu, BPC-157, TB-500, Semax, CJC-1295, ipamorelin, and bremelanotide (PT-141)

These conditions are also typified by loss of mitochondrial health through dysfunction of homeostatic components such as mitophagy, unfolded protein response, and the antioxidant system

Others handle it at embarkation with no pre-notification required