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As LPO as well as iron deposition are prominent features of atherosclerotic plaques [79], it is rational to deduce that ferroptosis in ECs, VMSCs, and macrophages may be implicated in the progression of atherosclerotic plaque destabilization

doi: 10.1515/reveh-2016-0064 80 TylerCRJoblingSSumpterJP

In a clinical trial conducted in colon cancer patients on FOLFOX therapy (Table 2), GM1 attenuated symptoms of acute neuropathy (cold sensitivity, throat discomfort, muscle cramps), but its use to prevent the neurotoxicity of oxaliplatin is currently not recommended, and additional placebo-controlled studies are needed to better assess the utility of this agent in this clinical condition [4, 67]

GSH deficiency may contribute to the nephrotoxicity of ischemic events and drug toxicity
[Google Scholar] Strobel NA, Peake JM, Matsumoto A, Marsh SA, Coombes JS & Wadley GD (2011)
M2 microglia extracellular vesicle miR-124 regulates neural stem cell differentiation in ischemic stroke via AAK1/NOTCH
