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Furthermore, secreted apolipoprotein E (ApoE) from melanoma cells modulates ferroptosis sensitivity by decreasing peroxidation-prone PUFA content and enhancing GPX4 levels, contributing to ferroptosis resistance and correlating with poor patient prognosis ( Tumor suppressor genes such as p53 and BAP1 also intricately regulate ferroptosis sensitivity in melanoma

Mouse model of focal cerebral ischemia using endothelin-1

Molecular Biomedicine 6(1), 2025

(2) Researchers find that naturally occurring peptides may occasionally exhibit instability and easy degradation by biological enzymes, such as those found in gastrointestinal and cerebrospinal fluids

For proteomic analysis of secretomes, cells were treated or untreated with cisplatin as indicated above

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