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Compounds with dual GLP1RA/GIPRA activity have been developed, and it has been suggested that even when the specific contribution of the GIPRA to weight loss is unclear, it may promote weight loss by modulating GLP-1 signaling (79)

In addition, combination trials in which vitamin B12 was used in significant doses in conjunction with other treatments (most often other B vitamins, including vitamin B1 and vitamin B6) also showed benefits for diabetic neuropathy (41-43)

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Gydesen S, Andreassen KV, Hjuler ST, et al