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Several mechanisms have been proposed to explain chronic hyperglycemia-induced nerve damage, such as intracellular accumulation of sorbitol, glycation reactions, and oxidative and nitrosative stress (reviewed in 69)

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Int J Mol Sci 23(1):480 Violi F, Cammisotto V, Bartimoccia S, Pignatelli P, Carnevale R, Nocella C
Tendon and ligament fibroblast cultures examining outgrowth rate, collagen organization, and growth-factor receptor expression after mechanical or chemical injury

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[DOI] [PubMed] [Google Scholar] 31.Padwal RS, Majumdar SR