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Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK

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2021-2023: SURMOUNT Weight Management Program Four Phase 3 trials specifically evaluated weight reduction in participants without diabetes [3] : SURMOUNT-1: Pivotal 72-week trial (n=2,539) showing up to 22.5% total body weight loss with 15 mg dosethe highest weight loss ever reported for a pharmacological obesity intervention SURMOUNT-2: Obesity trial in participants with type 2 diabetes achieving 15.7% weight loss [5] SURMOUNT-3: Withdrawal study demonstrating 6.7% weight regain in placebo group vs

J Gastroenterol 2004;39(10):948-54

Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells
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