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Methods 64 , 207215 (2005)

We established an inducible Ire1-null mouse line by crossing the conditional Ern1 f/f mouse strain 28 ( Ern1 is the gene symbol for Ire1 in mice) with the Rosa26-CreERT2 strain 29 to generate the Ern1 f/f ;Rosa26-CreERT2 + mice