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2017;12:e0172868

Murabito AS (Smith Kline & French Laboratories, Philadelphia, PA): Personal communication

Clinical, Cosmetic and Investigational Dermatology 2014:7 submit your manuscript | www.dovepress.com Dovepress Dovepress 272 Watanabe et al Table 3 Benecial effects of GSSG treatment of skin, as scored by investigator and subjects Week 0 2 4 6 8 10 Group Placebo GSSG Placebo GSSG Placebo GSSG Placebo GSSG Placebo GSSG Placebo GSSG N 30 30 30 30 30 30 30 30 30 30 30 30 Investigator Skin whitening Score 0 100.0 100.0 100.0 100.0 100.0 76.7 90.0 13.3 46.7 3.3 33.3 0.0 Score 1 0.0 0.0 0.0 0.0 0.0 23.3 10.0 73.3 53.3 60.0 63.3 33.3 Score 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.3 0.0 36.7 3.3 66.7 Wrinkle reduction Score 0 100.0 100.0 96.7 100.0 100.0 83.3 100.0 76.7 96.7 40.0 76.7 10.0 Score 1 0.0 0.0 3.3 0.0 0.0 13.3 0.0 13.3 3.3 40.0 23.3 56.7 Score 2 0.0 0.0 0.0 0.0 0.0 3.3 0.0 10.0 0.0 20.0 0.0 33.3 Subjects Skin whitening Score 0 100.0 100.0 100.0 100.0 100.0 76.7 90.0 13.3 46.7 3.3 16.7 0.0 Score 1 0.0 0.0 0.0 0.0 0.0 23.3 10.0 73.3 53.3 63.3 60.0 23.3 Score 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.3 0.0 33.3 23.3 76.7 Wrinkle reduction Score 0 100.0 100.0 100.0 100.0 100.0 83.3 100.0 80.0 96.7 46.7 63.3 16.7 Score 1 0.0 0.0 0.0 0.0 0.0 13.3 0.0 10.0 3.3 33.3 36.7 53.3 Score 2 0.0 0.0 0.0 0.0 0.0 3.3 0.0 10.0 0.0 20.0 0.0 30.0 Note: Data are expressed as percentages of the total number of subjects

In addition, therapeutic strategies that focus on modulating bile acid signaling pathways hold promise for the development of targeted therapies and interventions aimed at managing various gastrointestinal, metabolic, and cardiovascular disorders