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Unlike sequence-guided methods that rely on native viral motifs, this strategy typically employs heterologous pairssuch as the MS2 coat protein (MCP) or PP7 (PCP) systemswhere an aptamer hairpin is integrated into the target RNA while the ABP is genetically fused to the VLP structural protein (Unti and Jaffrey, 2023)

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Seromas, infection, asymmetry, implant migration or malposition, implant rupture, and capsular contracture occur with incidences between 1 to 5%

This systemic effect is unique to injectable administration and explains why many researchers prefer this route

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