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In the IMPROVE-IT trial lowering LDL-C with ezetimibe and the ODYSSEY and FOURIER trials using PCSK9 inhibitors a greater reduction in ASCVD events was observed in high risk patients (see reference (40) for discussion of these studies)

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: Prime Kraft 1

2015;10(10):e0141454

The trade-off is a steeper decline

Photodamage Reduction: Trials have investigated its role in protecting against non-melanoma skin cancer and photoinduced skin diseases
