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Description
Persistent NRF2 signaling, frequently mediated by the p62-KEAP1-NRF2 axis, promotes survival by activating ARE-dependent genes such as SLC7A11 , glutathione peroxidase 4 ( GPX4 ), NQO1 , HO-1 , and FTH1 , which limit lipid peroxidation, regulate iron homeostasis, and protect against ferroptosis

Sackmann-Sala L, et al

doi: 10.1016/0092-8674(95)90039-X
Several well-travelled IGF-IR signaling pathways cross-talk with those downstream from TSHR in thyroid epithelial cells

10.1007/BF03179824

Physical improvements in body composition largely persist if lifestyle factors remain consistent