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smaller than the circle that surrounds the Lincoln Memorial (99 feet high)

The other treatments usually need to be continued throughout life

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

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Despite the promise of this nanopore strategy, several challenges remain: (1) the geometry and chemistry of the nanopores must be precisely tailored to accommodate the bulky lipase, complicating the synthetic steps, and (2) the orientation of the lipase within the nanopore is unpredictable, making interfacial activation a trial-and-error process, which can result in suboptimal efficiency