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Enhancing mitochondrial health can create a more robust cellular environment, potentially improving the overall response to senolytic interventions

Vitamin B12 (B12) is an essential cofactor for two enzymes involved in onecarbon metabolism: methylmalonyl CoA mutase (reduced function of this enzyme results in increased serum methylmalonyl acid (MMA) levels) and methionine synthetase (this enzyme catalyzes the remethylmation of homocysteine to methionine)

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The same HGF plasmid (VM-202) was also evaluated in ALS patients in order to define its tolerability and safety profile (NCT02039401)